Integrated preclinical and clinical development of S-trans, trans-farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer

PURPOSE: S-trans,trans-Farnesylthiosalicylic Acid (FTS, salirasib) inhibits Ras-dependent cell growth by dislodging all isoforms of Ras, including mutant Ras, from the plasma membrane. This study evaluated the activity, safety, and toxicity of salirasib in preclinical models and patients with metast...

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Detalhes bibliográficos
Main Authors: Laheru, Daniel, Shah, Preeti, Rajeshkumar, N. V., McAllister, Florencia, Taylor, Gretchen, Goldsweig, Howard, Le, Dung T., Donehower, Ross, Jimeno, Antonio, Linden, Sheila, Zhao, Ming, Song, Dongweon, Rudek, Michelle A., Hidalgo, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557459/
https://ncbi.nlm.nih.gov/pubmed/22547163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9818-6
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