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Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1
The polyketide natural product Leptomycin B inhibits nuclear export mediated by the karyopherin protein chromosomal region maintenance 1 (CRM1). Here, we present 1.8- to 2.0-Å-resolution crystal structures of CRM1 bound to Leptomycin B and related inhibitors Anguinomycin A and Ratjadone A. Structura...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557022/ https://ncbi.nlm.nih.gov/pubmed/23297231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217203110 |
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