Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

The polyketide natural product Leptomycin B inhibits nuclear export mediated by the karyopherin protein chromosomal region maintenance 1 (CRM1). Here, we present 1.8- to 2.0-Å-resolution crystal structures of CRM1 bound to Leptomycin B and related inhibitors Anguinomycin A and Ratjadone A. Structura...

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Bibliografiska uppgifter
Huvudupphovsmän: Sun, Qingxiang, Carrasco, Yazmin P., Hu, Youcai, Guo, Xiaofeng, Mirzaei, Hamid, MacMillan, John, Chook, Yuh Min
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2013
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557022/
https://ncbi.nlm.nih.gov/pubmed/23297231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217203110
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