Peroxisome proliferator-activated receptor gamma (PPARγ) regulates thrombospondin-1 and Nox4 expression in hypoxia-induced human pulmonary artery smooth muscle cell proliferation

Transforming growth factor-β1 (TGF- β1) and thrombospondin-1 (TSP-1) are hypoxia-responsive mitogens that promote vascular smooth muscle cell (SMC) proliferation, a critical event in the pathogenesis of pulmonary hypertension (PH). We previously demonstrated that hypoxia-induced human pulmonary arte...

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Hlavní autoři: Green, David E., Kang, Bum-Yong, Murphy, Tamara C., Hart, C. Micheal
Médium: Artigo
Jazyk:Inglês
Vydáno: Medknow Publications & Media Pvt Ltd 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555419/
https://ncbi.nlm.nih.gov/pubmed/23372933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/2045-8932.105037
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