(18)F-FLT-PET for Response Evaluation of MEK Inhibitor Selumetinib (AZD6244, ARRY-142886) in Patients with Solid Tumors

Selumetinib (AZD6244, ARRY-142886) is a potent, selective, uncompetitive inhibitor of MEK 1 / 2, part of the RAF/MEK/ERK protein kinase signal cascade, which is responsible for tumor. This pilot study was used to explore if (18)F-fluoro-l-thymidine (FLT), a thymidine analogue positron emission tomog...

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Autors principals: Desar, Ingrid M. E., Gilles, Rozemarie, van Herpen, Carla M. L., Timmer-Bonte, Anja (J.) N. H., Cantarini, Mireille V., van der Graaf, Winette T. A., Oyen, Wim J. G.
Format: Artigo
Idioma:Inglês
Publicat: Medknow Publications & Media Pvt Ltd 2012
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555396/
https://ncbi.nlm.nih.gov/pubmed/23372439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1450-1147.103413
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