Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

IL-1β is a potent pro-inflammatory cytokine produced in response to infection or injury. It is synthesized as an inactive precursor that is activated by the protease caspase-1 within a cytosolic molecular complex called the inflammasome. Assembly of this complex is triggered by a range of structural...

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Main Authors: Lopez-Castejon, Gloria, Luheshi, Nadia M., Compan, Vincent, High, Stephen, Whitehead, Roger C., Flitsch, Sabine, Kirov, Aleksandr, Prudovsky, Igor, Swanton, Eileithyia, Brough, David
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554938/
https://ncbi.nlm.nih.gov/pubmed/23209292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422238
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