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The Fidelity of Transcription: RPB1 (RPO21) MUTATIONS THAT INCREASE TRANSCRIPTIONAL SLIPPAGE IN S. CEREVISIAE

The fidelity of RNA synthesis depends on both accurate template-mediated nucleotide selection and proper maintenance of register between template and RNA. Loss of register, or transcriptional slippage, is particularly likely on homopolymeric runs in the template. Transcriptional slippage can alter t...

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Autors principals: Strathern, Jeffrey, Malagon, Francisco, Irvin, Jordan, Gotte, Deanna, Shafer, Brenda, Kireeva, Maria, Lubkowska, Lucyna, Jin, Ding Jun, Kashlev, Mikhail
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554935/
https://ncbi.nlm.nih.gov/pubmed/23223234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.429506
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