A Genetic Assay for Transcription Errors Reveals Multilayer Control of RNA Polymerase II Fidelity

We developed a highly sensitive assay to detect transcription errors in vivo. The assay is based on suppression of a missense mutation in the active site tyrosine in the Cre recombinase. Because Cre acts as tetramer, background from translation errors are negligible. Functional Cre resulting from ra...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Irvin, Jordan D., Kireeva, Maria L., Gotte, Deanna R., Shafer, Brenda K., Huang, Ingold, Kashlev, Mikhail, Strathern, Jeffrey N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168980/
https://ncbi.nlm.nih.gov/pubmed/25232834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004532
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