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Lysine 63-linked Ubiquitination Modulates Mixed Lineage Kinase-3 Interaction with JIP1 Scaffold Protein in Cytokine-induced Pancreatic β Cell Death

The mixed lineage kinase MLK3 plays a crucial role in compromising mitochondrial integrity and functions as a proapoptotic competence factor in the early stages of cytokine-induced pancreatic β cell death. In an effort to identify mechanisms that regulate MLK3 activity in β cells, we discovered that...

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Autori principali: Humphrey, Rohan K., Yu, Shu Mei A., Bellary, Aditi, Gonuguntla, Sumati, Yebra, Myra, Jhala, Ulupi S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554912/
https://ncbi.nlm.nih.gov/pubmed/23172226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.425884
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