Loss of TRB3 Alters Dynamics of MLK3-JNK Signaling and Inhibits Cytokine-activated Pancreatic Beta Cell Death

Disabling cellular defense mechanisms is essential for induction of apoptosis. We have previously shown that cytokine-mediated activation of the MAP3K MLK3 stabilizes TRB3 protein levels to inhibit AKT and compromise beta cell survival. Here, we show that genetic deletion of TRB3 results in basal ac...

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Détails bibliographiques
Auteurs principaux: Humphrey, Rohan K., Ray, Anamika, Gonuguntla, Sumati, Hao, Ergeng, Jhala, Ulupi S.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208007/
https://ncbi.nlm.nih.gov/pubmed/25204656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575613
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