The Dok-3/Grb2 Protein Signal Module Attenuates Lyn Kinase-dependent Activation of Syk Kinase in B Cell Antigen Receptor Microclusters

Recruitment of the growth factor receptor-bound protein 2 (Grb2) by the plasma membrane-associated adapter protein downstream of kinase 3 (Dok-3) attenuates signals transduced by the B cell antigen receptor (BCR). Here we describe molecular details of Dok-3/Grb2 signal integration and function, show...

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Detalhes bibliográficos
Main Authors: Lösing, Marion, Goldbeck, Ingo, Manno, Birgit, Oellerich, Thomas, Schnyder, Tim, Bohnenberger, Hanibal, Stork, Björn, Urlaub, Henning, Batista, Facundo D., Wienands, Jürgen, Engelke, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554902/
https://ncbi.nlm.nih.gov/pubmed/23223229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.406546
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