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Membrane heterogeneities in the formation of B cell receptor–Lyn kinase microclusters and the immune synapse

Antigen binding to the B cell receptors (BCRs) induces BCR clustering, phosphorylation of BCRs by the Src family kinase Lyn, initiation of signaling, and formation of an immune synapse. We investigated B cells as they first encountered antigen on a membrane using live cell high resolution total inte...

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Autori principali: Sohn, Hae Won, Tolar, Pavel, Pierce, Susan K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483512/
https://ncbi.nlm.nih.gov/pubmed/18644892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200802007
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