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Binding by the Hepatitis C Virus NS3 Helicase Partially Melts Duplex DNA
Binding of NS3 helicase to DNA was investigated by footprinting with KMnO(4), which reacts preferentially with thymidine residues in ssDNA compared to those in dsDNA. A distinct pattern of reactivity was observed on ssDNA, which repeated every 8 nt and is consistent with the known binding site size...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554864/ https://ncbi.nlm.nih.gov/pubmed/22916835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300654v |
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