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Binding by the Hepatitis C Virus NS3 Helicase Partially Melts Duplex DNA

Binding of NS3 helicase to DNA was investigated by footprinting with KMnO(4), which reacts preferentially with thymidine residues in ssDNA compared to those in dsDNA. A distinct pattern of reactivity was observed on ssDNA, which repeated every 8 nt and is consistent with the known binding site size...

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Main Authors: Raney, Veronica M., Reynolds, Kimberly A., Harrison, Melody K., Harrison, David K., Cameron, Craig E., Raney, Kevin D.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554864/
https://ncbi.nlm.nih.gov/pubmed/22916835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300654v
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