Hepatitis C Virus NS3 Helicase Forms Oligomeric Structures That Exhibit Optimal DNA Unwinding Activity in Vitro

HCV NS3 helicase exhibits activity toward DNA and RNA substrates. The DNA helicase activity of NS3 has been proposed to be optimal when multiple NS3 molecules are bound to the same substrate molecule. NS3 catalyzes little or no measurable DNA unwinding under single cycle conditions in which the conc...

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Bibliografski detalji
Glavni autori: Sikora, Bartek, Chen, Yingfeng, Lichti, Cheryl F., Harrison, Melody K., Jennings, Thomas A., Tang, Yong, Tackett, Alan J., Jordan, John B., Sakon, Joshua, Cameron, Craig E., Raney, Kevin D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Enzyme Catalysis and Regulation
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431078/
https://ncbi.nlm.nih.gov/pubmed/18283103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708125200
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