NS3 Helicase from the Hepatitis C Virus Can Function as a Monomer or Oligomer Depending on Enzyme and Substrate Concentrations

Hepatitis C virus NS3 helicase can unwind double-stranded DNA and RNA and has been proposed to form oligomeric structures. Here we examine the DNA unwinding activity of monomeric NS3. Oligomerization was measured by preparing a fluorescently labeled form of NS3, which was titrated with unlabeled NS3...

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Bibliographische Detailangaben
Hauptverfasser: Jennings, Thomas A., Mackintosh, Samuel G., Harrison, Melody K., Sikora, Deniz, Sikora, Bartek, Dave, Bhuvanesh, Tackett, Alan J., Cameron, Craig E., Raney, Kevin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643493/
https://ncbi.nlm.nih.gov/pubmed/19088075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805540200
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