Hepatitis C Virus NS3 Helicase Forms Oligomeric Structures That Exhibit Optimal DNA Unwinding Activity in Vitro

HCV NS3 helicase exhibits activity toward DNA and RNA substrates. The DNA helicase activity of NS3 has been proposed to be optimal when multiple NS3 molecules are bound to the same substrate molecule. NS3 catalyzes little or no measurable DNA unwinding under single cycle conditions in which the conc...

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Main Authors: Sikora, Bartek, Chen, Yingfeng, Lichti, Cheryl F., Harrison, Melody K., Jennings, Thomas A., Tang, Yong, Tackett, Alan J., Jordan, John B., Sakon, Joshua, Cameron, Craig E., Raney, Kevin D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431078/
https://ncbi.nlm.nih.gov/pubmed/18283103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708125200
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