Molecular Determinants of Epidermal Growth Factor Binding: A Molecular Dynamics Study

The epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinase family that plays a role in multiple cellular processes. Activation of EGFR requires binding of a ligand on the extracellular domain to promote conformational changes leading to dimerization and transphosphorylat...

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Bibliographic Details
Main Authors: Sanders, Jeffrey M., Wampole, Matthew E., Thakur, Mathew L., Wickstrom, Eric
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554757/
https://ncbi.nlm.nih.gov/pubmed/23382875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054136
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