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Molecular Determinants of Epidermal Growth Factor Binding: A Molecular Dynamics Study
The epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinase family that plays a role in multiple cellular processes. Activation of EGFR requires binding of a ligand on the extracellular domain to promote conformational changes leading to dimerization and transphosphorylat...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554757/ https://ncbi.nlm.nih.gov/pubmed/23382875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054136 |
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