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Ligand binding and dynamics of the monomeric epidermal growth factor receptor ectodomain

The ectodomain of the human epidermal growth factor receptor (hEGFR) controls input to several cell signalling networks via binding with extracellular growth factors. To gain insight into the dynamics and ligand binding of the ectodomain, the hEGFR monomer was subjected to molecular dynamics simulat...

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Detalhes bibliográficos
Publicado no:Proteins
Main Authors: Loeffler, Hannes H, Winn, Martyn D
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282322/
https://ncbi.nlm.nih.gov/pubmed/23760854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24339
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