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Suppression of HIV-1 Infection by APOBEC3 Proteins in Primary Human CD4(+) T Cells Is Associated with Inhibition of Processive Reverse Transcription as Well as Excessive Cytidine Deamination
The Vif protein of human immunodeficiency virus type 1 (HIV-1) promotes viral replication by downregulation of the cell-encoded, antiviral APOBEC3 proteins. These proteins exert their suppressive effects through the inhibition of viral reverse transcription as well as the induction of cytidine deami...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554184/ https://ncbi.nlm.nih.gov/pubmed/23152537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02587-12 |
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