Unusual Features of Vaccinia Virus Extracellular Virion Form Neutralization Resistance Revealed in Human Antibody Responses to the Smallpox Vaccine

The extracellular virion form (EV) of vaccinia virus (VACV) is essential for viral pathogenesis and is difficult to neutralize with antibodies. Why this is the case and how the smallpox vaccine overcomes this challenge remain incompletely understood. We previously showed that high concentrations of...

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Hauptverfasser: Benhnia, Mohammed Rafii-El-Idrissi, Maybeno, Matthew, Blum, David, Aguilar-Sino, Rowena, Matho, Michael, Meng, Xiangzhi, Head, Steven, Felgner, Philip L., Zajonc, Dirk M., Koriazova, Lilia, Kato, Shinichiro, Burton, Dennis R., Xiang, Yan, Crowe, James E., Peters, Bjoern, Crotty, Shane
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554146/
https://ncbi.nlm.nih.gov/pubmed/23152530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02152-12
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