Unusual Features of Vaccinia Virus Extracellular Virion Form Neutralization Resistance Revealed in Human Antibody Responses to the Smallpox Vaccine

The extracellular virion form (EV) of vaccinia virus (VACV) is essential for viral pathogenesis and is difficult to neutralize with antibodies. Why this is the case and how the smallpox vaccine overcomes this challenge remain incompletely understood. We previously showed that high concentrations of...

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Main Authors: Benhnia, Mohammed Rafii-El-Idrissi, Maybeno, Matthew, Blum, David, Aguilar-Sino, Rowena, Matho, Michael, Meng, Xiangzhi, Head, Steven, Felgner, Philip L., Zajonc, Dirk M., Koriazova, Lilia, Kato, Shinichiro, Burton, Dennis R., Xiang, Yan, Crowe, James E., Peters, Bjoern, Crotty, Shane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554146/
https://ncbi.nlm.nih.gov/pubmed/23152530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02152-12
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