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Combination therapy of vaccinia virus infection with human anti-H3 and anti-B5 monoclonal antibodies in a small animal model

Vaccinia virus possesses two immunologically distinct virion forms in vivo—mature virion (MV, IMV) and extracellular virion (EV, EEV). Here we show that combination therapy with two fully human mAbs against an immunodominant MV antigen, H3 (H3L), and an EV antigen, B5 (B5R), provides significantly b...

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Hlavní autoři: McCausland, Megan M., Benhnia, Mohammed Rafii-El-Idrissi, Crickard, Lindsay, Laudenslager, John, Granger, Steven W., Tahara, Tomoyuki, Kubo, Ralph, Koriazova, Lilia, Kato, Shinichiro, Crotty, Shane
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898516/
https://ncbi.nlm.nih.gov/pubmed/20587859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP1573
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