Combination therapy of vaccinia virus infection with human anti-H3 and anti-B5 monoclonal antibodies in a small animal model

Vaccinia virus possesses two immunologically distinct virion forms in vivo—mature virion (MV, IMV) and extracellular virion (EV, EEV). Here we show that combination therapy with two fully human mAbs against an immunodominant MV antigen, H3 (H3L), and an EV antigen, B5 (B5R), provides significantly b...

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Detalhes bibliográficos
Main Authors: McCausland, Megan M., Benhnia, Mohammed Rafii-El-Idrissi, Crickard, Lindsay, Laudenslager, John, Granger, Steven W., Tahara, Tomoyuki, Kubo, Ralph, Koriazova, Lilia, Kato, Shinichiro, Crotty, Shane
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898516/
https://ncbi.nlm.nih.gov/pubmed/20587859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP1573
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