STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition

The DNA-binding specificity and affinity of the dimeric human transcription factor (TF) STAT1, were assessed by total internal reflectance fluorescence protein-binding microarrays (TIRF-PBM) to evaluate the effects of protein phosphorylation, higher-order polymerization and small-molecule inhibition...

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Main Authors: Bonham, Andrew J., Wenta, Nikola, Osslund, Leah M., Prussin, Aaron J., Vinkemeier, Uwe, Reich, Norbert O.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Gene Regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553987/
https://ncbi.nlm.nih.gov/pubmed/23180800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1085
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