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Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function
Signal transducer and activator of transcription STAT5 is essential for the regulation of proliferation and survival genes. Its activity is tightly regulated through cytokine signaling and is often upregulated in cancer. We showed previously that the deacetylase inhibitor trichostatin A (TSA) inhibi...
Shranjeno v:
| izdano v: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4402521/ https://ncbi.nlm.nih.gov/pubmed/25769527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv188 |
| Oznake: |
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