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Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function

Signal transducer and activator of transcription STAT5 is essential for the regulation of proliferation and survival genes. Its activity is tightly regulated through cytokine signaling and is often upregulated in cancer. We showed previously that the deacetylase inhibitor trichostatin A (TSA) inhibi...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nucleic Acids Res
Main Authors: Pinz, Sophia, Unser, Samy, Buob, Dominik, Fischer, Philipp, Jobst, Belinda, Rascle, Anne
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402521/
https://ncbi.nlm.nih.gov/pubmed/25769527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv188
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