Evidence against a Role for β-Arrestin1 in STAT1 Dephosphorylation and the Inhibition of Interferon-γ Signaling

Signal transducer and activator of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-γ (IFNγ) stimulation, which results in the expression of genes with antiproliferative and immunomodulatory functions. The inactivation of STAT1 occurs through tyrosine dephosphorylatio...

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Autores principales: Pelzel, Christin, Begitt, Andreas, Wenta, Nikola, Vinkemeier, Uwe
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2013
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Matters Arising
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898874/
https://ncbi.nlm.nih.gov/pubmed/23582260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.02.024
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