Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics

Trypanosoma brucei survives in mammals through antigenic variation, which is driven by RAD51-directed homologous recombination of Variant Surface Glycoproteins (VSG) genes, most of which reside in a subtelomeric repository of >1000 silent genes. A key regulator of RAD51 is BRCA2, which in T. bruc...

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Hlavní autoři: Trenaman, Anna, Hartley, Claire, Prorocic, Marko, Passos-Silva, Danielle G., van Hoek, Moniek, Nechyporuk-Zloy, Volodymyr, Machado, Carlos R., McCulloch, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553974/
https://ncbi.nlm.nih.gov/pubmed/23222131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1192
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