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Selection of tRNA charging quality control mechanisms that increase mistranslation of the genetic code
Mistranslation can follow two events during protein synthesis: production of non-cognate amino acid:transfer RNA (tRNA) pairs by aminoacyl-tRNA synthetases (aaRSs) and inaccurate selection of aminoacyl-tRNAs by the ribosome. Many aaRSs actively edit non-cognate amino acids, but editing mechanisms ar...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3553970/ https://ncbi.nlm.nih.gov/pubmed/23222133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1240 |
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