Interactions of Oximino-Substituted Boronic Acids and β-Lactams with the CMY-2-Derived Extended-Spectrum Cephalosporinases CMY-30 and CMY-42

CMY-30 and CMY-42 are extended-spectrum (ES) derivatives of CMY-2. ES characteristics are due to substitutions of Gly (CMY-30) and Ser (CMY-42) for Val211 in the Ω-loop. To characterize the effects of 211 substitutions, we studied the interactions of CMY-2, -30, and -42 with boronic acid transition...

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Bibliographic Details
Main Authors: Kotsakis, Stathis D., Caselli, Emilia, Tzouvelekis, Leonidas S., Petinaki, Efi, Prati, Fabio, Miriagou, Vivi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553701/
https://ncbi.nlm.nih.gov/pubmed/23229484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01620-12
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