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Comparative Biochemical and Computational Study of the Role of Naturally Occurring Mutations at Ambler Positions 104 and 170 in GES β-Lactamases

In GES-type β-lactamases, positions 104 and 170 are occupied by Glu or Lys and by Gly, Asn, or Ser, respectively. Previous studies have indicated an important role of these amino acids in the interaction with β-lactams, although their precise role, especially that of residue 104, remains uncertain....

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kotsakis, Stathis D., Miriagou, Vivi, Tzelepi, Eva, Tzouvelekis, Leonidas S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976113/
https://ncbi.nlm.nih.gov/pubmed/20696873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00771-10
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