Increased Hydrolysis of Oximino-β-Lactams by CMY-107, a Tyr199Cys Mutant Form of CMY-2 Produced by Escherichia coli

The cephalosporinase CMY-107, a Tyr199Cys mutant form of CMY-2 encoded by an IncI self-transferable plasmid carried by an Escherichia coli clinical strain, was characterized. The enzyme hydrolyzed oximino-cephalosporins and aztreonam more efficiently than CMY-2 did.

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Kotsakis, S. D., Miriagou, V., Vetouli, E. E., Bozavoutoglou, E., Lebessi, E., Tzelepi, E., Tzouvelekis, L. S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649145/
https://ncbi.nlm.nih.gov/pubmed/26438499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01793-15
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