Autophagy is involved in endogenous and NVP-AUY922-induced KIT degradation in gastrointestinal stromal tumors

Gastrointestinal stromal tumor (GIST) is a prototype of mutant KIT oncogene-driven tumor. Prolonged tyrosine kinase inhibitor (TKI) treatment may result in a resistant phenotype through acquired secondary KIT mutation. Heat shock protein 90 (HSP90AA1) is a chaperone protein responsible for protein m...

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Bibliografiske detaljer
Main Authors: Hsueh, Yuan-Shuo, Yen, Chueh-Chuan, Shih, Neng-Yao, Chiang, Nai-Jung, Li, Chien-Feng, Chen, Li-Tzong
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Translational Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552885/
https://ncbi.nlm.nih.gov/pubmed/23196876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.22802
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