Selecting Tyrosine Kinase Inhibitors for Gastrointestinal Stromal Tumor with Secondary KIT Activation-Loop Domain Mutations

Advanced gastrointestinal stromal tumors (GIST), a KIT oncogene-driven tumor, on imatinib mesylate (IM) treatment may develop secondary KIT mutations to confer IM-resistant phenotype. Second-line sunitinib malate (SU) therapy is largely ineffective for IM-resistant GISTs with secondary exon 17 (acti...

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Main Authors: Hsueh, Yuan-Shuo, Lin, Chih-Lung, Chiang, Nai-Jung, Yen, Chueh-Chuan, Li, Chien-Feng, Shan, Yan-Shen, Ko, Ching-Huai, Shih, Neng-Yao, Wang, Ling-Mei, Chen, Ting-Shou, Chen, Li-Tzong
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688691/
https://ncbi.nlm.nih.gov/pubmed/23840364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065762
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