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Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity
Mutations in GBA, the gene encoding glucocerebrosidase, the lysosomal enzyme deficient in Gaucher disease increase the risk for developing Parkinson disease. Recent research suggests a relationship between glucocerebrosidase and the Parkinson disease-related amyloid-forming protein, α-synuclein; how...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3552326/ https://ncbi.nlm.nih.gov/pubmed/23266198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2012.11.010 |
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