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A Chimeric Kinesin-1 Head/Kinesin-5 Tail Motor Switches between Diffusive and Processive Motility

Homotetrameric kinesin-5 motors are essential for chromosome separation and assembly of the mitotic spindle. These kinesins bind between two microtubules (MTs) and slide them apart, toward the spindle poles. This process must be tightly regulated in mitosis. In in vitro assays, Eg5 moves diffusively...

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Main Authors: Thiede, Christina, Lakämper, Stefan, Wessel, Alok D., Kramer, Stefanie, Schmidt, Christoph F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Biophysical Society 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552264/
https://ncbi.nlm.nih.gov/pubmed/23442865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.11.3810
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