A Chimeric Kinesin-1 Head/Kinesin-5 Tail Motor Switches between Diffusive and Processive Motility

Homotetrameric kinesin-5 motors are essential for chromosome separation and assembly of the mitotic spindle. These kinesins bind between two microtubules (MTs) and slide them apart, toward the spindle poles. This process must be tightly regulated in mitosis. In in vitro assays, Eg5 moves diffusively...

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Autors principals: Thiede, Christina, Lakämper, Stefan, Wessel, Alok D., Kramer, Stefanie, Schmidt, Christoph F.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2013
Matèries:
Molecular Machines, Motors, and Nanoscale Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552264/
https://ncbi.nlm.nih.gov/pubmed/23442865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.11.3810
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