Force-Dependent Detachment of Kinesin-2 Biases Track Switching at Cytoskeletal Filament Intersections

Intracellular trafficking of organelles often involves cytoskeletal track switching. Organelles such as melanosomes are transported by multiple motors including kinesin-2, dynein, and myosin-V, which drive switching between microtubules and actin filaments during dispersion and aggregation. Here, we...

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Main Authors: Schroeder, Harry W., Hendricks, Adam G., Ikeda, Kazuho, Shuman, Henry, Rodionov, Vladimir, Ikebe, Mitsuo, Goldman, Yale E., Holzbaur, Erika L.F.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2012
Teme:
Molecular Machines, Motors, and Nanoscale Biophysics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388211/
https://ncbi.nlm.nih.gov/pubmed/22828331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.05.037
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