Blockade of phospholipid scramblase 1 with its N-terminal domain antibody reduces tumorigenesis of colorectal carcinomas in vitro and in vivo

BACKGROUND: Membrane-bound phospholipid scramblase 1 (PLSCR1) is involved in both lipid trafficking and cell signaling. Previously, we showed that PLSCR1 is overexpressed in many colorectal carcinomas (CRCs). In the present study, we investigated the tumorigenic role of PLSCR1 in CRC and suggest tha...

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Detalhes bibliográficos
Main Authors: Fan, Chung-Wei, Chen, Chun-Yu, Chen, Kuei-Tien, Shen, Chia-Rui, Kuo, Yung-Bin, Chen, Ya-Shan, Chou, Yeh-Pin, Wei, Wei-Shan, Chan, Err-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551821/
https://ncbi.nlm.nih.gov/pubmed/23259795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-254
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