Blockade of phospholipid scramblase 1 with its N-terminal domain antibody reduces tumorigenesis of colorectal carcinomas in vitro and in vivo

BACKGROUND: Membrane-bound phospholipid scramblase 1 (PLSCR1) is involved in both lipid trafficking and cell signaling. Previously, we showed that PLSCR1 is overexpressed in many colorectal carcinomas (CRCs). In the present study, we investigated the tumorigenic role of PLSCR1 in CRC and suggest tha...

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Autors principals: Fan, Chung-Wei, Chen, Chun-Yu, Chen, Kuei-Tien, Shen, Chia-Rui, Kuo, Yung-Bin, Chen, Ya-Shan, Chou, Yeh-Pin, Wei, Wei-Shan, Chan, Err-Cheng
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551821/
https://ncbi.nlm.nih.gov/pubmed/23259795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-254
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