Massive ex vivo expansion of human natural regulatory T cells (Tregs) with minimal loss of in vivo functional activity

Graft-versus-host disease (GVHD) is a frequent and severe complication following hematopoietic cell transplantation. Natural CD4(+)25(+) regulatory T cells (nTregs) have proven highly effective in preventing GVHD and autoimmunity in murine models. Yet, clinical application of nTregs has been severel...

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Hauptverfasser: Hippen, Keli L., Merkel, Sarah C., Schirm, Dawn K., Sieben, Christine M., Sumstad, Darin, Kadidlo, Diane M., McKenna, David H., Bromberg, Jonathan S., Levine, Bruce L., Riley, James L., June, Carl H., Scheinberg, Phillip, Douek, Daniel C., Miller, Jeffrey S., Wagner, John E., Blazar, Bruce R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551476/
https://ncbi.nlm.nih.gov/pubmed/21593401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001809
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