First-in-human phase 1 trial of induced regulatory T cells for graft-versus-host disease prophylaxis in HLA-matched siblings

Human CD4(+)25(−) T cells cultured in interleukin 2 (IL-2), rapamycin, and transforming growth factor β (TGFβ) along with anti-CD3 monoclonal antibody–loaded artificial antigen-presenting cells generate FoxP3(+) induced regulatory T cells (iTregs) with potent suppressive function. We performed a pha...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: MacMillan, Margaret L., Hippen, Keli L., McKenna, David H., Kadidlo, Diane, Sumstad, Darin, DeFor, Todd E., Brunstein, Claudio G., Holtan, Shernan G., Miller, Jeffrey S., Warlick, Erica D., Weisdorf, Daniel J., Wagner, John E., Blazar, Bruce R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948291/
https://ncbi.nlm.nih.gov/pubmed/33666654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003219
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