First-in-human phase 1 trial of induced regulatory T cells for graft-versus-host disease prophylaxis in HLA-matched siblings

Human CD4(+)25(−) T cells cultured in interleukin 2 (IL-2), rapamycin, and transforming growth factor β (TGFβ) along with anti-CD3 monoclonal antibody–loaded artificial antigen-presenting cells generate FoxP3(+) induced regulatory T cells (iTregs) with potent suppressive function. We performed a pha...

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Pubblicato in:Blood Adv
Autori principali: MacMillan, Margaret L., Hippen, Keli L., McKenna, David H., Kadidlo, Diane, Sumstad, Darin, DeFor, Todd E., Brunstein, Claudio G., Holtan, Shernan G., Miller, Jeffrey S., Warlick, Erica D., Weisdorf, Daniel J., Wagner, John E., Blazar, Bruce R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2021
Soggetti:
Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948291/
https://ncbi.nlm.nih.gov/pubmed/33666654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003219
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