First-in-human phase 1 trial of induced regulatory T cells for graft-versus-host disease prophylaxis in HLA-matched siblings

Human CD4(+)25(−) T cells cultured in interleukin 2 (IL-2), rapamycin, and transforming growth factor β (TGFβ) along with anti-CD3 monoclonal antibody–loaded artificial antigen-presenting cells generate FoxP3(+) induced regulatory T cells (iTregs) with potent suppressive function. We performed a pha...

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Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: MacMillan, Margaret L., Hippen, Keli L., McKenna, David H., Kadidlo, Diane, Sumstad, Darin, DeFor, Todd E., Brunstein, Claudio G., Holtan, Shernan G., Miller, Jeffrey S., Warlick, Erica D., Weisdorf, Daniel J., Wagner, John E., Blazar, Bruce R.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2021
Matèries:
Transplantation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948291/
https://ncbi.nlm.nih.gov/pubmed/33666654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003219
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