First-in-human phase 1 trial of induced regulatory T cells for graft-versus-host disease prophylaxis in HLA-matched siblings

Human CD4(+)25(−) T cells cultured in interleukin 2 (IL-2), rapamycin, and transforming growth factor β (TGFβ) along with anti-CD3 monoclonal antibody–loaded artificial antigen-presenting cells generate FoxP3(+) induced regulatory T cells (iTregs) with potent suppressive function. We performed a pha...

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Veröffentlicht in:Blood Adv
Hauptverfasser: MacMillan, Margaret L., Hippen, Keli L., McKenna, David H., Kadidlo, Diane, Sumstad, Darin, DeFor, Todd E., Brunstein, Claudio G., Holtan, Shernan G., Miller, Jeffrey S., Warlick, Erica D., Weisdorf, Daniel J., Wagner, John E., Blazar, Bruce R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2021
Schlagworte:
Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948291/
https://ncbi.nlm.nih.gov/pubmed/33666654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003219
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