Optimization of cGMP Purification and Expansion of Umbilical Cord Blood-Derived T-Regulatory Cells in Support of First-in-Human Clinical Trials

BACKGROUND: Thymic-derived regulatory T cells (tTreg) are critical regulators of the immune system. Adoptive tTreg transfer is a curative therapy for murine models of autoimmunity, graft rejection, and graft versus host disease (GVHD). We previously completed a “first-in-human” clinical trial using...

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Detalhes bibliográficos
Publicado no:Cytotherapy
Main Authors: McKenna, David H., Sumstad, Darin, Kadidlo, Diane, Batdorf, Bjorn, Lord, Colin J., Merkel, Sarah C., Koellner, Christine M., Curtsinger, Julie M., June, Carl H., Riley, James L., Levine, Bruce L., Miller, Jeffrey S., Brunstein, Claudio G., Wagner, John E., Blazar, Bruce R., Hippen, Keli L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237605/
https://ncbi.nlm.nih.gov/pubmed/27887864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2016.10.011
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