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Stabilisation of an E3 ligase-E2-Ubiquitin complex increases cell surface MHC Class I expression
The Kaposi’s sarcoma-associated herpesvirus (KSHV) encoded ubiquitin E3 ligase, K3 ubiquitinates cell surface MHC class I molecules (MHC I), causing the internalisation and degradation of MHC I via the endolysosomal pathway. K3 recruits the cellular E2 ubiquitin conjugating enzyme, Ubc13 to generate...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3551299/ https://ncbi.nlm.nih.gov/pubmed/20483773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0904154 |
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