The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation

RNA-binding E3 ubiquitin ligases were recently identified, though their function remains unclear. While studying the regulation of the MHC class I (MHC-I) pathway, we here characterize a novel role for ubiquitin in mRNA degradation. MHC-I molecules provide ligands for both cytotoxic T-lymphocytes as...

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Hauptverfasser: Cano, Florencia, Bye, Helen, Duncan, Lidia M, Buchet-Poyau, Karine, Billaud, Marc, Wills, Mark R, Lehner, Paul J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433784/
https://ncbi.nlm.nih.gov/pubmed/22863774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.218
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