No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls

OBJECTIVES: Osteoarthritis (OA) has a complex aetiology with a strong genetic component. Genome-wide association studies implicate several nuclear genes in the aetiology, but a major component of the heritability has yet to be defined at the molecular level. Initial studies implicate maternally inhe...

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Detalhes bibliográficos
Main Authors: Hudson, Gavin, Panoutsopoulou, Kalliope, Wilson, Ian, Southam, Lorraine, Rayner, Nigel W, Arden, Nigel, Birrell, Fraser, Carluke, Ian, Carr, Andrew, Chapman, Kay, Deloukas, Panos, Doherty, Michael, McCaskie, Andrew, Ollier, William E R, Ralston, Stuart H, Reed, Mike R, Spector, Tim D, Valdes, Ana M, Wallis, Gillian A, Wilkinson, J Mark, Zeggini, Eleftheria, Samuels, David C, Loughlin, John, Chinnery, Patrick F
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2013
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551219/
https://ncbi.nlm.nih.gov/pubmed/22984172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2012-201932
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