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Conformational selection or induced-fit? A critical appraisal of the kinetic mechanism
For almost five decades, two competing mechanisms of ligand recognition – conformational selection and induced-fit - have dominated our interpretation of ligand binding in biological macromolecules. When binding/dissociation events are fast compared to conformational transitions, the rate of approac...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3550001/ https://ncbi.nlm.nih.gov/pubmed/22775458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3006913 |
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