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Ubiquitination in Signaling to and Activation of IKK
A role of polyubiquitination in the activation of IκB kinase (IKK) through a proteasome-independent mechanism was first reported in 1996, but the physiological significance of this finding was not clear until 2000 when TRAF6 was found to be a ubiquitin E3 ligase that catalyzes lysine-63 (K63) polyub...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549672/ https://ncbi.nlm.nih.gov/pubmed/22435549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-065X.2012.01108.x |
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