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A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK activation by TNFα and IL-1β
Lysine-63 (K63)-linked polyubiquitination has emerged as a mechanism regulating diverse cellular functions, including activation of the protein kinase IKK in the NF-κB pathways. However, genetic evidence for a key role of K63 polyubiquitination in IKK activation is lacking. Here we devise a tetracyc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2779160/ https://ncbi.nlm.nih.gov/pubmed/19854138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.10.002 |
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