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Cytoskeletal keratin glycosylation protects from epithelial tissue injury
Keratins 8 and 18 (K8/K18) are heteropolymeric intermediate filament phospho-glycoproteins of simple-type epithelia. K8/K18 protect hepatocytes from apoptosis and their mutations predispose to liver disease. K18 undergoes dynamic O-linked N-acetylglucosamine glycosylation at Ser30/31/49, the functio...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549664/ https://ncbi.nlm.nih.gov/pubmed/20729838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2091 |
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