p27(Kip1) Directly Represses Sox2 during Embryonic Stem Cell Differentiation

The mechanisms responsible for the transcriptional silencing of pluripotency genes in differentiated cells are poorly understood. We have observed that cells lacking the tumor suppressor p27 can be reprogrammed into induced pluripotent stem cells (iPSCs) in the absence of ectopic Sox2. Interestingly...

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Bibliografiske detaljer
Main Authors: Li, Han, Collado, Manuel, Villasante, Aranzazu, Matheu, Ander, Lynch, Cian J., Cañamero, Marta, Rizzoti, Karine, Carneiro, Carmen, Martínez, Gloria, Vidal, Anxo, Lovell-Badge, Robin, Serrano, Manuel
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2012
Fag:
Short Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549496/
https://ncbi.nlm.nih.gov/pubmed/23217425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.09.014
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